List of interstate highways

There are 70 primary Interstate Highways in the Interstate Highway System, a network of controlled-access freeways in the United States. They are assigned one- or two-digit route numbers, whereas their associated "auxiliary" Interstate Highways receive three-digit route numbers. Typically, odd-numbered Interstates run south-north, with lower numbers in the west and higher numbers in the east; even-numbered Interstates run west-east, with lower numbers in the south and higher numbers in the north. Highways whose route numbers are divisible by "5" usually represent major coast-to-coast or border-to-border routes (ex. I-10 travels from Santa Monica, California, to Jacksonville, Florida, traveling from the Pacific to Atlantic oceans). Additionally, auxiliary highways have their numbering system where a different number prefixes the number of its parent highway.

Five route numbers are duplicated in the system, though the corresponding highways are separated by state lines which prevent confusion. The main list that discusses the primary Interstate Highways in the contiguous United States is followed by sections regarding Alaska, Hawaii, and Puerto Rico.